Glutathione metabolism in hepatomous liver of rats treated with diethylnitrosamine
نویسندگان
چکیده
منابع مشابه
Invasiveness of hyperplastic nodule cells from diethylnitrosamine-treated rat liver.
Administration of diethylnitrosamine p.o. to female Sprague-Dawley rats induces hepatocellular lesions antecedent to hepatocarcinoma (altered foci and hyperplastic nodules). We have tested hepatocytes from hyperplastic nodules for their invasiveness in vitro, which is a marker for malignancy. The hyperplastic nodule cells are compared with control liver cells and hepatocarcinoma cells. Control ...
متن کاملInvestigation of curcumin effects on liver tissue in adult male rats treated with cyclophosphamide
Background & Objective: Cyclophosphamide is an antineoplastic drug that has many clinical uses in cancer treatment, but it has toxic effects due to creation of free radicals. In this study, the effects of curcumin" as an antioxidant drug” on liver tissue was investigated. Materials & methods: 50 wistar adult male rats were selected randomly and were divided in to five groups including co...
متن کاملMicrocirculation of hepatic nodules from diethylnitrosamine-treated rats.
The microcirculation of nodules (0.5 to 10 mm in diameter) from diethylnitrosamine-treated rats was studied in perfused livers. Microlight guides were placed on nodules and surrounding tissue on the capsular surface of the liver to measure fluorescence due to fluorescein-dextran (12 microM), a dye confined to the vascular space, infused via the hepatic artery and portal vein separately or simul...
متن کاملLiver transplantation for diethylnitrosamine-induced hepatocellular carcinoma in rats.
H UMAN hepatocellular carcinoma (HCC) is a highly malignant tumor with a natural history of a few months from the time of diagnosis. Curative resection offers the best chance of survival. l However, surgical resectability rates rarely exceed 30% to 40% because of extensiveness of the tumors or because coexisting liver disease precludes attempted partial hepatectomy.2 Consequently, total liver r...
متن کاملEffect of hydroalcoholic extract of ginger on the liver of epileptic female rats treated with lamotrigine
Objective: Lamotrigine is an antiepileptic drug, widely used in the treatment of epilepsy; long-term use of this drug can cause hepatotoxicity. Zingiber officinale Roscoe (ginger) possesses antioxidant properties. In present research, the effect ofhydroalcoholic extract of ginger (HEG) on the liver of lamotrigine-treated epileptic rats was investigated Material and Methods: Forty-eight female W...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 1997
ISSN: 0925-4439
DOI: 10.1016/s0925-4439(96)00075-0